Posts Tagged ‘genetics’

Autism is the Opposite of Schizophrenia

Wednesday, April 29th, 2009

The autism spectrum goes from neurotypical to nerdy to Asperger’s to autistic disorder. Some psychologists say that schizophrenia has a similar spectrum from neurotypical to gregarious to schizotypical to schizophrenia. These spectra fit together to form a full spectrum.

There’s a popular theory in philosophy of mind that autism is caused by a deficiency in the “theory of mind module”: the part of your brain that allows you to figure out what other people are thinking and see things from their point of view. It’s suggested that schizophrenia could be an overactive theory of mind: hallucinations are leaks from simulation of other minds, paranoid delusions arise from assuming that other people are thinking about you, etc.

It strikes me as rather stereotypical, but autism has also been framed as an overly “masculine” brain: a focus on things and logical thinking over people and play. Schizophrenia could be correspondingly “feminine”: high empathy and poor logic skills.

There’s some correlation between autism and high physical growth, and between schizophrenia and low physical growth (all covered in this paper so thorough, it must have been written by an autistic). So guess what the proposed cause of this spectrum of disorders is? Genome imprinting: your mom’s genes are trying to make you schizophrenic and your dad’s genes are trying to make you autistic; if they’re balanced, you end up neurotypical.

Your Mom Loves Your Siblings More Than You

Tuesday, April 28th, 2009

Growing and nursing a giant liger is a large investment for a mommy tigress. But the daddy lion is very pleased that his mate invests so much in their offspring. There’s a cool theory that genome imprinting is mostly used to achieve a balance between the paternal goal of investment in his children and the maternal goal of living to have another child (often with another father). Rather than an aggressive growth gene being bred out of the population, a gene evolves that counters it using imprinting.

In humans, the Prader-Willi and Angelman syndromes are caused by defects in a particular gene on the paternal and maternal chromosomes, respectively. Prader-Willi infants avoid breastfeeding and sleep a lot; around the age of weaning, they gain an insatiable appetite and interest in finding food (ie: do their own foraging and aren’t picky). Angelman children act extremely happy, getting greater emotional investment from their parents than their whiny siblings.

By far the biggest investment in growing a human fetus is the brain tissue, so we can assume that genome imprinting will turn out to be the cause of some neurological disorders…

Why are Ligers Bigger than Tigons?

Wednesday, April 22nd, 2009

Ligers (male lion + female tiger) are bigger than both lions and tigers, tigons (male tiger + female lion) are not. If I had to guess why, I would have said something to do with XY-chromosome sex differentiation. But female ligers, who have a lion X-chromosome and a tiger X-chromosome, are still big. What the hell?

For most chromosomes, a liger gets one from each parent. In highschool we’re taught that whether the mother’s gene or father’s gene gets activated depends on which one is “dominant”. That’s a gloss; genes don’t have dominance: both genes get activated and sometimes the effect of one is so powerful that it doesn’t matter what the other gene does. But if the lion gene says “grow to x” and the tiger gene says “grow to y”, it shouldn’t be the case that the liger grows to larger than both x and y.

I recently found out that the answer is a mechanism called genome imprinting: Chromosomes from each parent have different markers added by chromatin remodeling or methylation (together called epigenetics: I get the impression that which mechanism is unknown in almost all cases). There are genes that act differently or act on other genes differently depending on who they were inherited from.

So either lions have a maternally-imprinted gene and/or tigers have a paternally-imprinted gene that limits growth. And that’s why ligers are bred for their skills in magic.

Genetics is a Big Kludge

Tuesday, April 21st, 2009

In highschool you’re taught that DNA is a simple sequence of instructions read by machines in the cell (insert a bunch of useless knowledge about RNA). Depending on signalling chemicals in the cell’s environment, the machines follow the DNA code to build proteins that do stuff. I recently learned it’s way more complicated than that:

Autocrine signalling
A cell transmits chemical signals that attach to its own chemical receivers
Post-translational modification
A cell produces proteins that modify the other completed proteins inside the cell (including prions, which are inheritable via reproductive cells)
Post-transcriptional regulation
A cell produces proteins that modify the way other proteins are assembled in the cell
Chromatin remodeling
A cell produces proteins that control how the machines access the DNA, including making parts of it inaccessible (probably inheritable)
Methylation
A cell produces proteins that make temporary changes to the DNA (by covering in a chemical that blocks the machines, which is totally inheritable)
Copying errors
Currently believed to be random mutations, I predict that proteins will be discovered that affect how DNA is copied
Reverse transcription
Proteins (including retrovirii) in the cell write new genes into the DNA (when these get inherited they’re called endogenous retrovirii)

Most of these mechanisms are very poorly understood and the more research that gets done in them, the more significant they appear to be versus vanilla genetics. This is why the Human Genome Project has failed to give us superpowers.

All this reminds me of a long time ago, when computers were really expensive, programmers would write programs that modify themselves while they ran. They are impossible to read (you can’t just look at the code), and only crazy people could write them, so it is now considered extremely bad programming. In other words, if there is a God, I wouldn’t hire Him.